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Mozambique here we come..................

UCT may have found cure for Malaria


The University of Cape Town's science department believes it has found a single dose cure for Malaria.

CAPE TOWN - The University of Cape Town (UCT)'s Science department on Tuesday announced it has found a single dose cure for Malaria.
Science and Technology Minister Naledi Pandor was also present when the announcement was made.

Researchers have been hard at work for several years and now believe they have discovered a drug which may annihilate a mosquito’s parasitic life cycle.

Clinical trials are set to take place at the end of 2013.
The potent drug has been tested on animals and has shown that a single oral dose has completely cured those infected with malaria parasites.

This means that millions of people can potentially get cured.

At least 24 percent of child deaths in sub-Saharan Africa are due to malaria and globally, one million people die each year from the disease.

(Edited by Lindiwe Mlandu)

Serra Moz

UCT scientists are hopeful they are close to producing a single dose cure for malaria.

The malaria-killing compound, named MMV390048, was discovered at UCT by a team in collaboration with partners from all over the world, including Medicines for Malaria Venture.

The team have also been nominated as one of Medicines for Malaria Venture’s top research projects of last year and the winners will be announced on Friday.

According to UCT, the compound is very potent. In preclinical trials it killed the parasite in a single dose that was given to the subject orally.

It is also active against a number of resistant strains of the malaria parasite, which means it could potentially save millions of lives.

The compound was discovered in 2010 but only approved last year after receiving the go-ahead from the scientific advisory committee.

The scientists are due to embark on the human testing phase, that will take place at UCT and Groote Schuur Hospital early next year, and will begin the process of looking for volunteers towards the end of this year.

According to lead researcher Kelly Chibale, there will be three phases of human testing. According to Chibale, if all goes well there could be a final product within the next six to eight years.

“This molecule has the potential to be a part of a single dose cure. It is also a possibility that this dose could stay long in the human body and protect it,” said Chibale, who is UCT’s professor of Organic Chemistry and leads the H3-D team, which is a drug research centre based in Cape Town. The H3-D team focuses on TB and malaria based research.

The testing started with rats and mice before moving on to primates.

According to Chibale, the testing has been successful.

“We can use the data from the animal testing to project what might happen with humans,” he said.

Chibale stressed that before any testing on animals was done the group had to go through an ethical committee, saying that they were not allowed to just test anything on the animals that would cause them harm.

Chibale said they had received support from both UCT and the government.

“Research is not a luxury, it creates jobs while it is happening,” he said.

“African governments need to start understanding this.”

Chibale said that the success of this project would lead to more opportunities for research in Africa.

“This is the first major project and the most successful. We are now working on a TB project and expanding infrastructure and bringing in more expertise and experience,” he said.

There were only four full-time researchers when the project began in 2009.

There are now 22 full-time researchers and Chibale expected this number to grow further in the future. - Cape Times

Serra Moz

OTGman wrote:
More info about malaria prevention


Came across this today, I think it's good news.
Yes, indeed good news, will be good if they (Govts in Africa) can supply that at low cost or free to the people. Sometime ago, I watched a doccie about an Egyptian doctor/scientist that's using some plant extract (he would not name or show the raw product) anyway you wash or spray it your clothes/curtains or linen and it keeps the mozzies away for sometime - all natural.

I have been working & living in Malaria areas for years, only had it once...self inflicted? If you stick to the basic guidelines and precautions you'll be ok. With self inflicted I am having loads of beer and a huge braai - only shorts and a vest......night time in the summer in Moz....looking for Malaria.


New member
I was with the army 10 years back and was given mefloquine on long term basis when conducting survival training in forested area and anti-mosquito patch which is pasted onto the uniform lasting 1 day. Actually I am rather surprised that they are still researching on it. I wonder is it because those item we were using in the past are ineffective.

Serra Moz

I think it could be resistance, are a certain resistance to a specific type of malaria strain? Then again, I have read and heard some locals in Africa don't get malaria.